Search results for "Rat Adrenals"

showing 2 items of 2 documents

Zeitlicher Ablauf der ACTH-induzierten Stimulierung der Corticosteroidbiosynthese

1969

The time course of ACTH action was studied during incubation of quartered rat adrenals by estimation of corticosterone production and secretion rates. The results suggest a two step action of ACTH during the acute stimulation of corticosteroid biosynthesis: A modest initial stimulation was observed within the first 30 min of exposure to ACTH which was overlapped by a marked secondary stimulation between 30 and 60 min.

endocrine systemmedicine.medical_specialtymedicine.drug_classChemistryTwo stepStimulationRat Adrenalschemistry.chemical_compoundEndocrinologyCorticosteroneInternal medicineTime coursemedicineCorticosteroidSecretionIncubationhormones hormone substitutes and hormone antagonists
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Cholestenon in Rattennebennieren

1970

For the first time it has been proven that cholest-4-ene-3-one is an endogenous constituent of adrenal tissue. Concentrations of cholestenone in quartered rat adrenals after 3 hours of in vitro incubation were comparable to those of progesterone. However, from specific radioactivities of tissue cholesterol and progesterone and from those of tissue cholestenone and progesterone after incubations with either 4-14C-cholesterol or 4-14C-cholestenone it has been concluded that, at best, cholestenone plays a minimal role as a C27-intermediate of corticosteroid biosynthesis.

medicine.medical_specialtymedicine.drug_classEndogenyIn vitro incubationRat AdrenalsTissue cholesterolchemistry.chemical_compoundEndocrinologyBiosynthesischemistryInternal medicineAdrenal tissuemedicineCorticosteroid
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